RPLs can be used for the selective isolation of glycosylated biomolecules and could be used for the isolation of such molecules from milk to facilitate analysis and characterisation. The scalability of RPL production also enables their use for larger scale applications. They could therefore be used for manufacturing scale isolation of bioactive glycoproteins from milk. In addition to beneficial glycosylated molecules milk can also contain molecules displaying glycans that may have undesirable effects in vivo such as allergenic Gal-a(1,3)-Gal and Neu5Gc. These could elicit allergen like immune responses in humans although there is no established correlation to date between milk consumption and any such negative health effects. However, GlycoSeLect's RPLs could be used for the selective removal of these potential undesirable molecules from products.
Bovine Lactoferrin - is the most established milk glycoprotein used as an ingredient. It is known to have a wide range of beneficial activities for people of all ages including antimicrobial, immunomodulatory, prebiotic, and anticancer activities. It is used as a nutraceutical in infant formulae, fortified milks, iron supplements and drinks, immune-enhancing nutraceuticals, cosmetic formulae, animal and pet care supplements. Its production has been upscaled by a number of companies but it takes 50 to 100 thousand litres of milk to produce 1 kg of lactoferrin, hence its high cost at $500 to $1000 per kg.
RPLs represent useful tools for studying the glycobiology of the skin. They can be used as biochemical reagents in a wide range of assay formats or integrated into a analytical platforms to enable the detection and analysis of glycosylated biomolecules. They can also be immobilized onto solid support matrices and used for the selective isolation of glycosylated biomolecules to enable their characterisation.
The glycans attached to biomolecules and displayed on cell surfaces play many important biological roles including roles in maintaining the structure and health of the skin (Glycobiology & Skin Care). Exploring the glycobiology of the skin, and deciphering the underlying mechanisms important for skin health, is therefore a major area of interest to the cosmetics industry. The knowledge gained could contribute to the development of new and more effective skin care products.
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Glycobiology & the Food Industry
Glycobiology & Cosmetics
Human and animal milk are rich sources of of bioactive molecules including oligosaccharaides, glycolipids and glycoproteins. These play several important protective, physiological and biological roles including stimulation of growth of beneficial gut microbes, inhibition of pathogen adhesion, immunoregulation and roles in the development of the brain and nervous system. Because of this these molecules are of significant interest as ingredients to the functional food industry. Given its wide availability Bovine milk is an excellent source of these bioactive molecules and a potential starting material from which they could be isolated for subsequent use as additives in bioactive foods.